• Associate Professor, St. Ann’s college for women, Mehdipatnam, Hyd. Sep2024-March 2025

• Associate Professor and Head, Department of Chemistry, Sardar Patel College, Secunderabad,July 2023-Sep2024.

• Professor, Swarnandhra Institute of Engineering and Technology, Andhra Pradesh Jan2020 - Jul2023

•   Assistant Professor, NIPER Hyderabad, Apr 2017- 31 Jan 2020 and

• DST-SERB Scientist 2016-2019

•  Associate Professor, Padmasri B.V.Raju Institute of Technology, Narsapur, Medak, Jan2015- Apr 2017

•  Postdoctoral Research fellow in Medicinal Chemistry, Dr. Reddy’s Institute of Life sciences, University of Hyderabad, Hyderabad, May 2008- Dec 2012

• Junior Research Scientist in Medicinal Chemistry, Dr. Reddy’s Institute of Life sciences, University of Hyderabad, Hyderabad, Jan 2013-April 2014

•  CSIR SCIENTIST 2012-2014

• DST-FAST TRACK Young Scientist 2010-13

1. Ph.D. (Department of Chemistry, Indian Institute of Technology, Madras)

• Submitted: October, 2007, Defended: March, 2008

• Thesis Title: Effect of Additional Chirality in Aminodiol Ligand In

• Catalytic Asymmetric Michael Addition Reactions Using Heterobimetallics

•  Supervisor: Late Prof.G. Sundararajan and Prof. S. Sankararaman

2. M.Sc. (Organic Chemistry)

• •  Osmania University College of Science, OU Campus, Hyderabad, India

3. B.Sc. (Chemistry, Genetics, Botany)

• • University college for women, Osmania University, Koti,Hyderabad                                             

•  Award of DST-WIDUSHI grant 2025, ongoing

• Award of DST-SERB core grant, 2016-2019

• Award of CSIR grant under Sponsored Research Scheme 2012-2014

•  Award of DST-FAST TRACK grant 2010-13

•  Award of CSIR- NET 2001

• Graduate Aptitude Test, 1996, 93.12 percentile and AIR 123.

•  Merit scholarship, Rank in M.Sc at Osmania University, 1993.

•  School topper, in S.S.C and National Merit Scholarship.

• World Researchers Association

• Society for Electrocnalytical Chemistry

Journal Publication

1. Design, synthesis of DNA-interactive 4-thiazolidinone-based indolo-/pyrroloazepinone conjugates as potential cytotoxic and topoisomerase I inhibitors. Manasa Kadagathur, Sandip Patra, Geetanjali Devabattula, Joel George, Regur Phanindranath, Arbaz Sujat Shaikh, Dilep Kumar Sigalapalli, Chandraiah Godugu, Narayana Nagesh, Neelima D. Tangellamudi, Nagula Shankaraiah. European Journal of Medicinal Chemistry 2022, 238, 114465-84. DOI: 10.1016/j.ejmech.2022.114465. ISSN: 0009-4374

2. Arbaz Sujat Shaikh, Gaddam Kiranmai, G. Parimala Devi, Priyanka N. Makhal, Dilep Kumar Sigalapalli, Ramya Tokala, Venkata Rao Kaki, Nagula Shankaraiah, Narayana Nagesh, Bathini Nagendra Babu, Neelima D. Tangellamudi. Exploration of Mercaptoacetamide-inked Pyrimidine-1,3,4-Oxadiazole Derivatives as DNA Intercalative Topo II inhibitors: Cytotoxicity and Apoptosis Induction. Bioorganic and Medicinal Chemistry Letters. 2022, Letters.2022, 65, 128697-703. DOI: 10.1016/j.bmcl.2022.128697. ISSN: 0960-894X

3. Manasa Kadagathur, Arbaz Sujat Shaikh, Biswajit Panda Joel George, Regur Phanindranath, Dilep Kumar Sigalapalli, Nagesh A. Bhale, Chandraiah Godugu, Narayana Nagesh, Nagula Shankaraiah, Neelima D. Tangellamudi. Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors. Bioorg.,2022, 122, 105706-19. DOI: 10.1016/j.bioorg.2022.105706. ISSN: 0045-2068

4. Dilep Kumar Sigalapalli, Gaddam Kiranmai, Ramya Tokala, Chaturvedula Tripura, Ramesh Ambatwar, Saiprasad N. Nunewar, Manasa Kadagathur, Nagula Shankaraiah, Narayana Nagesh, Bathini Nagendra Babu, Neelima D. Tangellamudi. Targeting Tubulin Polymerization and DNA Binding of 4-Thiazolidinone-umbelliferone Hybrids: Synthesis and Cytotoxicity Evaluation. New J.Chem., 2021, 45, 18908-18923. DOI: 10.1039/d1nj03135j URL http://dx.doi.org/10.1039/d1nj03135j  ISSN: 1369-9261 

5. Dilep Kumar Sigalapalli, Gaddam Kiranmai, G. Parimala Devi, Ramya Tokala, Sravani Sana, Chaturvedula Tripura, Govinda S. Jadhav, Manasa Kadagathur, Nagula Shankaraiah, Narayana Nagesh*, Bathini Nagendra Babu, Neelima D. Tangellamudi. Synthesis and biological evaluation of novel imidazo[1,2-a] pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding. Bioorganic and Medicinal Chemistry, 2021, 43, 116277-89. DOI: 10.1016/j.bmc.2021.116277 URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85108630613&partnerID=MN8TOARS        ISSN: 0968-0896

6.  Manasa Kadagathur, Dilep Kumar Sigalapalli, Sandip Patra & Neelima D. Tangellamudi Microwave-assisted hydrogen peroxide-mediated synthesis of benzoxazoles and related heterocycles via cyclodesulfurization, Synthetic Communications, 2021, 51(14), 2213-2224. DOI: 10.1002/slct.202003516 URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-85106284328&partnerID=MN8TOARS        ISSN: 1532-2432

7. Manasa Kadagathur, Sandip Patra, Dilep Kumar Sigalapalli, Nagula Shankaraiah and Neelima D.Tangellamudi.Cyclodesulfurization: An Enabling Protocol for Synthesis of Various Heterocycles. ChemistrySelect, 2021, 6(10), 2621-2640. DOI: 10.1002/slct.202100201

   http://www.scopus.com/inward/record.url?eid=2-s2.0-85102523983&partnerID=MN8TOARSISSN: 23656549

8. Manasa Kadagathur, Sandip Patra, Dilep Kumar Sigalapalli, Nagula Shankaraiah and Neelima D.Tangellamudi. Syntheses and Medicinal Chemistry of Azepinoindolones: A Look Back to Leap Forward. Org. Biomol. Chem., 2021,19, 738-764. DOI: 10.1039/D0OB02181D URL https://doi.org/10.1039/D0OB02181D         ISSN: 1477-0539 

9. Dilep Kumar Sigalapalli, Vidyasrilekha Yele, Srikanth Jupudi, Arbaz Sujat Shaikh, Manasa Kadagathur, Neelima D. Tangellamudi, Nagendra Babu Bathini. Insights into the pharmacophore-based 3D-QSAR modeling, molecular dynamics simulation studies of certain dihydroxy pyrrolidine/piperidine and aza-flavanone derivatives as α-glucosidase inhibitors

   J. Mol.Struct., 2021, 1223, 129243-54. DOI: 10.1016/j.molstruc.2020.129243  URL http://www.scopus.com/inward/record.url?eid=2-               s2.0-85090824485&partnerID=MN8TOARS Print ISSN: 00222860

10. Dilep Kumar Sigalapalli, Manasa Kadagathur, Arbaz Sujat Shaikh, Govinda S. Jadhav, Bulti Bakchi, Nagendra Babu Bathini, Neelima D. Tangellamudi. Microwave-Assisted TBHP-Mediated Synthesis of 2-Amino-1,3,4-Oxadiazoles in Water. ChemistrySelect, 2020, 5, 13248-13258. DOI: 10.1002/slct.202003516 URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85096071943&partnerID=MN8TOARSISSN: 23656549

11. Saiprasad N. Nunewar, Komal G. Sangu, Naveen K. Kotla and Neelima D. Tangellamudi. Oxidative Dearomatization as a Strategy for a Facile, Metal-free Synthesis of Vanillyl Benzodiazepines. ChemistrySelect, 2020, 5, 10015-21. DOI: 10.1002/slct.202002523

        URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85089994426&partnerID=MN8TOARS  ISSN:  23656549                

12. Dilep Kumar Sigalapalli, Venkatesh Pooladanda, Manasa Kadagathur, Sravanthi Devi Guggilapu, Jaya Lakshmi Uppu, Chandraiah Godugu, Nagendra Babu Bathini, and Neelima D. Tangellamudi. Novel Chromenyl-Based 2-Iminothiazolidin-4-one Derivatives as Tubulin Polymerization Inhibitors: Design, Synthesis, Biological Evaluation and Molecular Modelling Studies. J. Mol.Struct., 2020, 1225,128847-61. DOI: 10.1016/j.molstruc.2020.128847 http://www.scopus.com/inward/record.url?eid=2-s2.0-85089886503&partnerID=MN8TOARS                Print ISSN: 00222860

13. Dilep Kumar Sigalapalli, Raghu Rangaswamy and Neelima D. Tangellamudi. Novel Huperzine A based NMDA antagonists: Insights from Molecular Docking, ADME/T and Molecular Dynamics Simulation Studies. RSC Adv., 2020, 10, 25446-25455. DOI: 10.1039/D0RA00722F URL https://doi.org/10.1039/D0RA00722FISSN: 2046-2069

14. Manasa Kadagathur, G. Parimala Devi, Preeti Grewal, Dilep Kumar Sigalapalli, Priyanka N. Makhal, Uttam Chand Banerjee, Nagendra Babu Bathini, Neelima D. Tangellamudi. Novel diindoloazepinone Derivatives as DNA Minor Groove Binding Agents with Selective Topoisomerase I Inhibition: Design, Synthesis, Biological Evaluation and Docking Studies

   Bioorg., 2019, 99, 103629-46.DOI: 10.1016/j.bioorg.2020.103629 URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85082670909&partnerID=MN8TOARS  ISSN: (ONLINE) 10902120 (PRINT) 00452068

15. Saiprasad N. Nunewar, Naveen Kotla, Apoorva Dixit and Neelima D. Tangellamudi. Synthesis of 1-(Indol-2-yl)-Phenoxazine Hybrids from Quinacetophenone Precursor as DNA intercalating agents. J. Mol. Struct., 2020, 1217, 128311-128322. DOI: 10.1016/j.molstruc.2020.128311 URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85084340963&partnerID=MN8TOARS Print ISSN: 00222860

16. Saiprasad N. Nunewar,Bhavana B. Muthyala, Sowmya Dastari,and Neelima D. Tangellamudi.* Quinacetophenone: A Simple Precursor for Synthesis of Phenoxazines. New J.Chem.,2019, 43, 14952-14960. DOI: 10.1039/c9nj03525gURL http://www.scopus.com/inward/record.url?eid=2-s2.0-85072611226&partnerID=MN8TOARS        ISSN: 1369-9261 

17. Sigalapalli Dilep Kumar, Venkatesh Pooladanda, Priti Singh, Manasa Kadagathur, Sravanthi Devi Guggilapu, Jaya Lakshmi Uppu,  Neelima D. Tangellamudi,* Pavan Kumar Gangireddy, Chandraiah Godugu. Discovery of certain benzyl/phenethyl thiazolidinone-indole hybrids as potential anti-proliferative agents: Synthesis, molecular modeling and tubulin polymerization inhibition study. Bioorg., 2019. 92, 103188-103196. DOI: 10.1016/j.bioorg.2019.103188 URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85071041111&partnerID=MN8TOARS        ISSN: 0045-2068

18. N. D. Tangellamudi,* S. B. Shinde, V. Pooladanda, C. Godugu, S. Balasubramanian, Facile synthesis of 2-aryl 5-hydroxy benzo[d]oxazoles and their in vitro antiproliferative effects on various cancer cell lines. Bioorg Med Chem Lett.,2018, 28, 3639-47. DOI: 10.1016/j.bmcl.2018.10.038URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85055651436&partnerID=MN8TOARSISSN: 0960-894X

19. Balakrishna Dulla, Neelima D. Tangellamudi,* Sridhar Balasubramanian, Pushkar Kulkarni, Javed Iqbal, Oliver Reiser, and Manojit Pal. Isovanillin derived N-(un)substituted hydroxylamines possessing ortho-allylic group: valuable precursors to novel bioactive N-heterocycles. Org. Biomol. Chem., 2014, 12, 2552-58. DOI: 10.1039/c3ob42460j URL http://www.scopus.com/inward/record.url?eid=2-s2.0-84897078943&partnerID=MN8TOARS        ISSN: 1477-0539 

20. Javed Iqbal, Neelima. D. Tangellamudi,* Balakrishna Dulla and Sridhar Balasubramanian. Sequential C-N and C-O bond Formation in Single pot: Synthesis of 2H-     benzo[b][1,4]oxazines from 2,5-dihydroxybenzaldehyde and Aminoacid precursors. Org. Lett., 2012, 14, 552-555. DOI: 10.1021/ol2031747 URL http://www.scopus.com/inward/record.url?eid=2-s2.0-84856096316&partnerID=MN8TOARS        ISSN: 1523-7052

21. Neelima. D. Tangellamudi*and Sundararajan G. Unexpected chemoselectivity of cyclic enones on introducing additional chirality in diethanolamine ligand in catalytic asymmetric Michael addition reactions using heterobimetallics. J. Mol.Cat. A: Chemical., 2009, 314, 71-80. DOI: 10.1016/j.molcata.2009.08.019 http://www.scopus.com/inward/record.url?eid=2-s2.0-71749092444&partnerID=MN8TOARS EID: 2-s2.0-71749092444 Print ISSN: 1381-1169

22. Neelima. D. Tangellamudi, Babu Varghese and Sundararajan G. Highly efficient resolution of racemic diethanolamine using (-) camphor-10-sulphonic acid. Arkivoc, 2005, xi, 137-145. EID: 2-s2.0-15744395428 URL http://www.scopus.com/inward/record.url?eid=2-s2.0-15744395428&partnerID=MN8TOARSISSN: 1551-7012

Book Chapters

Rajasekhara Reddy, Sabbasani, Sathi, Bhulakshmi, P., Sridhar, Tangellamudi, Neelima D. and Doddi, Adinarayana. “Chapter 11: Synthesis of bioactive heterocycles via click reaction". Non-Conventional Synthesis: Bioactive Heterocycles, edited by György Keglevich and Bubun Banerjee, Berlin, Boston: De Gruyter, pp. 307-336, 2024.

https://doi.org/10.1515/9783110980189-011

Attended/Presented

1.  Design, Molecular Docking, ADME/T and Molecular Dynamics Simulation Studies of Huperzine A Analogues: Virtual Identification of NMDA Receptor Antagonists. Dilep Kumar Sigalapalli, Raghu Rangaswamy and Neelima D. Tangellamudi. 29 Feb-2March, 2020 at the International Conference on Drug Discovery. BITS Pilani, Hyderabad campus.

2.  Novel Chromenyl Based 2-Iminothiazolidin-4-one Derivatives as Tubulin Polymerization Inhibitors: Design, Synthesis, Biological Evaluation and Docking Studies. Dilep Kumar Sigalapalli, Venkatesh Pooladanda, Chandraiah Godugu, Bathini Nagendra Babu, Neelima D. Tangellamudi. PhD Poster Symposium organized by Royal Society of Chemistry, December 21, 2019, at NIPER Hyderabad.

3.      Synthesis Of 1-(Indol-2-yl)-Phenoxazine Hybrids From Quinacetophenone Precursors And Their Biological Evaluation As DNA Intercalating Agents. Saiprasad N. Nunewar, Naveen kotla, Jaya Lakshmi Uppu, Apoorva Dixit, Venkatesh Pooladanda,  Chandraiah Godugu,b  Neelima D. Tangellamudi. PhD Poster Symposium organized by Royal Society of Chemistry, December 21, 2019, at NIPER Hyderabad (won the Best Poster award).

4.      Design, Synthesis and Biological Evaluation of Novel Seleno Thiophene-3-carboxamides. Priyanka N. Makhal, Prasanna Kumar, T. Venu, Neelima D. Tangellamudi. PhD Poster Symposium organized by Royal Society of Chemistry, December 21, 2019, at NIPER Hyderabad.

5.      Design, synthesis and biological evaluation of novel azepinodiindolone derivatives as potential DNA-intercalating antitumor agents”. Manasa Kadagathur, G. Parimala Devi, Dilep Kumar Sigalapalli, Priyanka N. Makhal, Nagendra Babu Bathini, Neelima D. Tangellamudi. At the International Conference On Pure And Applied Chemistry – IconPAC 2019", organized by K L University, Vijayawada, on March8-9, 2019 at K L University, Vijayawada, Andhra Pradesh, India (won the Best Poster award).

6.      Design and Synthesis of Novel 5- Substituted Thiazole Carboxamides as Possible Bcl-2 Inhibitors. D. Sowmya, N. Saiprasad and Neelima D. Tangellamudi. PhD Poster Symposium organized by Royal Society of Chemistry, January 9, 2019, at NIPER Hyderabad.

7.      Oxidative dearomatization strategy for facile metal- free synthesis of vanillyl based benzodiazepines. Komal Sangu and Neelima D. Tangellamudi. PhD Poster Symposium organized by Royal Society of Chemistry, January 9, 2019, at NIPER Hyderabad

8.  Introducing additional chirality in the chiral ligands. Is more the merrier?”. Neelima, T.D and Sundararajan, G. Oral presentation at the Second J-NOST symposium, October 11-14, 2006 at CCG, Jaipur, Rajasthan.

9.  Unexpected chemo selectivity in catalytic Michael addition reaction using heterobimetallics. Effect of chiral auxiliary on the ligand”. Neelima, T.D and Sundararajan, G. CRSI, July 12-14, 2006 at IIT Madras, Chennai.

10.  Catalytic asymmetric Michael addition of malonates: Effect of the chiral auxiliary on the amine group of the chiral ligand”. Neelima, T.D and Sundararajan, G. International conference, OCCB-2006, January 6-9, 2006 at NCL Pune, Pune.

11. Synthesis and structure related studies of novel chiral ligands to be used in asymmetric synthesis”. Neelima, T.D and Sundararajan, G. Chemists meet, March 26-27, 2004 at Indian Institute of Technology Madras.

Workshops

Organized/ convened

1. Convener, workshop on spectral analysis for determination of structure of organic molecules, July 5-6, 2024, SP College, Hyderabad

2. Co-Organized National Workshop on “Regulatory Compliance For Accelerating Innovations” Jointly organized by BIRAC (DBT) and Clinical Development Services Agency, at NIPER Hyderabad, 29 May, 2019.

3. Co-Organized Workshop on Drug Discovery & Development - Concept, Clinic & Commercialization (D3C3) by NIPER Hyderabad in collaboration with Novartis Academic Connect, at NIPER Hyderabad, in three modules on 16-17 Feb, 2018; 9-10 March, 2018; 13-14 April, 2019.

• • • • Research Guidance

                                        Guided 2 Doctoral students for PhD

1.    Mr. Dileep Kumar Sigalapalli:  NIPER-Hyderabad, July 2021.

• • • • Thesis title: “Synthesis and Biological Evaluation of Novel Iminothiazolidinone/ Coumarin/ Oxadiazole Derivatives as Potential Anticancer Agents and Designing of Novel Biologically Active Compounds by Using Computational Approach”

2. Ms. Manasa Kadagathur:, NIPER-Hyderabad, April July 2021

• • • • Thesis title: Design, Synthesis and Biological Evaluation of Indoloazepine-Containing Heterocyclic Compounds as Potential Anti-Cancer Agents

      • ·  Guided 15 MS dissertation students as Research guide

Invited Lectures

1. Talk on Facile synthesis of benzoxazoles and their anti-proliferative effect of various cancer cell lines, at World Drug Discovery Congress, Bengaluru, September 25-26, 2018.

2. Talk on Synthesis, Biological evaluation and Molecular Docking studies of Novel indolo/pyrroloazepinone- oxindole conjugates as potential anti-proliferative agents with Topo I inhibitory capability at 2nd Global Virual Congress on Cancer Research, October 17-18, 2022

3. Talk on Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Indolo/pyrroloazepinone-4-thiazolidinone Conjugates as Potent Antiproliferative Agents with Topo I Inhibitory Capability at 3rd Global Virtual Congress on Cancer Research & Drug Development, May 15, 2023·          

Dr. T. D. Neelima

Senior Women Scientist

Department of Electrical and Electronics Engineering

W-207, BITS-Pilani, Hyderabad Campus

Jawahar Nagar, Shameerpet

Hyderabad 500078, India

Email: neelima.td@hyderabad.bits-pilani.ac.in (W) groomprabhu@gmail.com (P)